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At position fifteen, the amino acid histidine (His) is replaced with a modified amino acid called D-Phenylalanine (D-Phe)

To increase its bioactivity and bioavailability resveratrol is encapsulated inside liposomes which acts as an ideal solution for its activity as resveratrol is less soluble in water

The most parsimonious hypothesis is simply that this is a case of a viral protease targeting a cellular gene for cleavage, for which there are abundant precedents, including the proposed M pro targeting of TRMT1 and HDAC2 (9), and HIV-1 protease, which can be toxic to cells, via its action at various cellular targets (15)

Mahr, S., Neumayer, N., Kolb, H.J., Schepp, W., Classen, M