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Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window

The medication should be stored in its original packaging or container, which is typically designed to provide adequate light protection

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Another polymeric nanogel delivery system of teriflunomide-loaded lipid-based carbopol-gellan gum in situ gel was reported by Kokare and co-wokers