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In the 2024 WADA Prohibited List (World Anti-Doping Agency, 2024c) Section 4: hormone and metabolic modulators, AIs (Subsection S4.1) and anti-estrogenic substances, including anti-estrogens and SERMs (Subsection S4.2), are prohibited at all times (in- and out-of-competition)

Key Facts Key Takeaways Friction is the primary cause topical treatment is slowest when daily rubbing continues creating new pigmentation Daily TKA soap + 23 weekly body scrub is the most effective natural combination Visible fading typically starts around week 68

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While some individuals may notice subtle improvements in appetite, sleep, or energy shortly after starting treatment, most benefits develop gradually over time as the body responds to the peptides signaling effects