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Animal studies on obesity The most compelling data comes from studies in diet-induced obese mice

Some health issues can change how much B12 is needed

Cells with higher NAD+ are more metabolically active and burn more calories at rest

It is used in the treatment and prevention of vitamin B12 deficiency in patients with conditions such as: Addisonian (pernicious) anemia Malabsorption Atrophic gastritis Prolonged treatment with metformin Small bowel bacterial overgrowth (SIBO) Total or partial gastrectomy Infection with the fish parasite Diphyllobothrium latum Helicobacter pylori infection Pancreatic dysfunction Pancreatic or bowel malignancy Dietary deficiency (e.g