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Cell 168 , 344361 (2017)

Minimum dietary fat threshold for effective ketogenesis and obesity control in mice

3.2.2 Downregulate expressions of cyclooxygenase-2 and inducible nitric oxide synthase Overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are correlated to colorectal carcinogenesis, and inhibition of their activities leads to cancer prevention ( 3.2.3 Downregulate expression of NF-B and upregulate expression of Nrf-2 NF-B regulated inflammatory responses and its activation lead to increased expression of pro-inflammatory cytokines, while nuclear factor-erythroid 2related factor 2 (Nrf-2) reduced the synthesis of inflammatory mediators by inhibiting the NF-B (Thimmulappa et al., 2016)

phospho-mTOR (Ser2448), mTOR (all from sigma)