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Leucovorin (High dose folinic acid) showed improvements in: Overall ASD symptoms (67%) Irritability (58%) Coordination, balance & speech (88%) Pyramidal signs (76%) Movement disorders (47%) Epilepsy (75%) Twenty-one studies treated individuals with autism using Leucovorin

The educational background of the participants varied, with 51.5% classified as having attained a high level of education, 30.3% a middle level, and 18.2% a low level of educational achievement

The total course of Accutane usually lasts about twenty weeks