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Ice crystal formation during freezing damages peptide structure

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After the combined use of a low concentration of APBMV (20 mg/L, cell inhibition rate is only 15.5%) and chemotherapeutic drugs such as mitomycin (MMC), DDP, fluorouracil (5-FU), and VP-16, the sensitivity of colorectal cancer LoVo cells to chemotherapeutic drugs increased and the cell inhibition rate even Increased to about 2 times that of those drugs used alone