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Similarly, quality of life, as assessed by the SF-36 (one patient had a total of four data points missing), showed significant improvements from baseline in the active treatment group for pain and physical functioning in contrast to the placebo group (Figure 6)

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First, in the system construction phase, the initial structure of the target molecule (such as a protein-ligand complex) must be determined, and environmental factors such as solvent molecules (e.g., water) and ions must be added