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Table 1 Inhibitors of the metabolic pathways, their influence on Treg cells and disease applied

IJMS 20 , 2358 (2019)

The action of glutathione on oxidative stress has led to speculation on the possible therapeutic role of this molecule for several chronic diseases with altered redox balance

in fact, it plays a critical role in both systemic and peripheral tissue inflammation and triggers high levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-) or interleukin-1/6 (Il-1/6) that have been indicted as the main cytokines secreted by macrophages and adipose tissue [18], creating a not-favorable microenvironment that impairs adipose tissue stem cells (ASC) multilineage differentiation potential [19], viability, and apoptosis, as well as autophagy and mitophagy [20] as well as oxidative stress that impairs ASC immunomodulatory potential [21]