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2019;14:e0225931

Individual missed doses have minimal impact on overall protocol outcomes

Research has shown that vitamin D deficiency or insufficiency contributes to the seasonal nature of cold and flu outbreaks less sunlight means less vitamin D production in the skin, which is linked to lower immunity and the possibility of more illness

Functional enrichment analysis revealed that the differentially expressed FRGs were involved mainly in the pathogenesis of EOPE and were enriched in pathways related to hypoxia and iron metabolism, such as response to hypoxia, regulation of iron homeostasis, and iron ion binding