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Description

Mechanistically, similar to SSO, an irreversible inhibitor of CD36, PSELT mitigated the senescence-induced upregulation of CD36, a key player in cardiac aging

Specifically, it is derived from the FOXO (Forkhead box O) family of transcription factors, which are part of the larger forkhead family

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In contrast, under antioxidant/low-ROS conditions (such as in certain tumor microenvironments or after treatment with BPC157 in our study), BACH1 becomes stabilized and can switch to promoting angiogenesis by directly activating target genes like VEGF