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A 2019 proof-of-concept study in Human Reproduction (Romero-Ruiz et al.) provided the earlier human data: kisspeptin treatment induced gonadotropic responses and rescued ovulation in a subset of women with PMOS, demonstrating direct clinical translation from the animal work

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2022), has shown that VEST was effective in mitigating vein graft disease proliferation 12 months post-CABG in all subgroups, with more pronounced effects in diabetic patients, who had higher risk for vein graft disease and MACCE