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However, the concentration of chondroitin sulfate decreases while keratin sulfate increases with aging

Physical therapy remains essential throughout recovery, directing newly formed tissue along functional stress lines and preventing the premature loading that causes most setbacks

In critical sized segmental defect in a rat radius, application of inorganic bone matrix together with P-15 resulted in positive effect on bone healing, without any immunogenic features and disease transmission risk [133]

The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle