In some histological and electrophysiological experiments, AgRP-IRES-Cre or LepR-IRES-Cre mice were also crossed with the Cre-inducible tdTomato-reporter mouse (B6;129S6-Gt(ROSA)26Sor tm9(CAG-tdTomato)Hze /J, The Jackson Laboratory), allowing the visualization of AgRP or LepR neurons via expression of the tdTomato fluorescent protein

Timestamps 00:00 Cold open: 200 years of menopause medicine 03:23 Welcome and roadmap 04:20 The HPG axis, follicles, and the FSH lag 09:11 STRAW+10 staging and the timing of perimenopause 13:47 Austin: the 49-year-old with a hormone panel 20:00 Loraine: the OB-GYN workup 28:00 Symptom attribution: what menopause actually causes 33:46 Austin: the all-estrogen patient 37:58 VMS duration and the KNDy mechanism (Avis, SKYLIGHT) 43:53 Austin: who actually gets fezolinetant 47:22 The WHI 24-year correction (Manson, Chlebowski, Boardman) 01:00:15 Modern prescribing today 01:06:52 Where the menopause-content space gets it right and wrong 01:11:50 Testosterone, compounded bioidenticals, and DUTCH panels 01:24:13 Takeaways What we cover The HPG axis and the estrogen shield: what is happening across the 35-year reproductive era and what changes at perimenopause
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Its gentle, vegan-friendly formula absorbs effortlessly into the skin, leaving the complexion soft, nourished, and revitalized with every use
The peptide stimulates production of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), both essential for follicle health and blood supply to the scalp