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While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3][10]

Another study suggested that glutathione deficiency may play a significant role in the pathophysiology of type 2 diabetes

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97 demonstrated that hypoalbuminemia which is often associated with malnutrition, contributed to subnormal ALP levels