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and increased hydrolysis of MTXPGs by lysosomal gamma-glutamyl hydrolases (GGH) (2325), although the influence of GGH on MTX efficacy remains controversial (2628)

AMG 133 demonstrated significant dose-dependent weight loss in a phase 1 randomized, double-blind, placebo-controlled clinical trial involving participants with obesity, along with an acceptable safety and tolerability profile [124]