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Anti-inflammatory and antioxidant effects: GHK-Cu downregulates pro-inflammatory cytokines (like IL-6) and upregulates antioxidant enzymes (such as superoxide dismutase)

doi: 10.1038/nature12726 73 SmithPMHowittMRPanikovNMichaudMGalliniCABohloolyYMet al

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Specifically, GHK-Cu was found to be least possible to cause skin irritation, while CuCl 2 and Cu(OAc) 2 were found to induce the expression of various skin irritation biomarkers, i.e., IL-1, IL-8, FOSL1, and HSPA1A