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An anti-HIF-1 agent, EZN-2968, a reverse complementary oligonucleotide inhibitor, has been demonstrated to block the interaction between multiple myeloma plasma cells and their microenvironment and is currently in late-stage clinical trials (NCT01120288) to verify its safety and efficacy

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Soluble autoimmunity markers B lymphocyte activating factor (BAFF) has been identified in many autoimmune diseases (519) as it regulates survival and maturation of B cells to control the IL-10 production of regulatory B cells (520, 521)

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